Chemistry Heterocyclic Building Blocks Imidazoles Imidazo[1,2-C]Pyrimidine

Imidazo[1,2-C]Pyrimidine

Nucleophilic Substitution: Imidazo[1,2-c]pyrimidine can undergo nucleophilic substitution reactions at various positions on the ring system. For example, nucleophiles can attack the electrophilic carbon atoms in the imidazole and pyrimidine rings. Electrophilic Substitution: Imidazo[1,2-c]pyrimidine can also undergo electrophilic aromatic substitution reactions. This can involve the addition of electrophilic reagents to the aromatic rings, leading to the substitution of hydrogen atoms with various functional groups. Oxidation and Reduction Reactions: The nitrogen atoms in the imidazole and pyrimidine rings can undergo oxidation or reduction reactions to yield different compounds with altered properties. Alkylation and Acylation: Imidazo[1,2-c]pyrimidine can react with alkyl or acyl halides in the presence of a base to introduce alkyl or acyl groups onto the nitrogen atoms. Cyclization Reactions: Depending on the reaction conditions and reagents, imidazo[1,2-c]pyrimidine can participate in various cyclization reactions, leading to the formation of fused ring systems or other heterocyclic compounds. Cross-Coupling Reactions: Imidazo[1,2-c]pyrimidine can be used in cross-coupling reactions, where it serves as a partner in the formation of new carbon-carbon or carbon-heteroatom bonds. Ring Opening Reactions: Under certain conditions, imidazo[1,2-c]pyrimidine can undergo ring-opening reactions, leading to the cleavage of the fused ring system and the formation of open-chain compounds.

Further Reading:

Framework+−

1,1'-Diphenyl-4,4',5,5'-Tetrahydro-1H,1'H-2,2'-Biimidazole 1,2-Dimethyl-1H-Imidazole 1,3-Diphenyl-1H-Imidazol-3-Ium 1,3-Diphenyl-4,5-Dihydro-1H-Imidazol-3-Ium 1-(Imidazo[1,2-A]Pyridin-3-Yl)Ethan-1-One 1-(Phenylsulfonyl)-1H-Imidazole 1-Benzyl-1H-Imidazole 1-Decyl-3-Methyl-1H-Imidazol-3-Ium 1-Ethyl-1H-Imidazole 1-Isopropyl-1H-Imidazole 1-Phenyl-1H-Imidazole-4-Carboxylic Acid 1-Trityl-1H-Imidazole 1H-Imidazo[4,5-B]Pyridine 1H-Imidazo[4,5-C]Pyridine 1H-Imidazol-2-Amine 1H-Imidazole-2-Carboxylic Acid 1H-Imidazole-4-Carbonitrile 1H-Imidazole-4-Carboxylic Acid 2-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole 2-Bromo-1H-Imidazole 2-Bromoimidazo[1,2-A]Pyridine 2-Ethyl-1H-Imidazole 2-Methyl-1-Phenyl-1H-Imidazole 2-Methylimidazo[1,2-A]Pyridine 2-Phenyl-1H-Benzo[D]Imidazole 2-Phenyl-1H-Imidazole 2-Phenylimidazo[1,2-A]Pyridine 2-Propyl-1H-Imidazole 3-Bromoimidazo[1,2-A]Pyrazine 3-Bromoimidazo[1,2-A]Pyridine 3-Bromoimidazo[1,2-A]Pyrimidine 3-Iodoimidazo[1,2-A]Pyridine 3-Methylimidazo[1,2-A]Pyridine 4,5,6,7-Tetrahydro-3H-Imidazo[4,5-C]Pyridine 4-(1H-Imidazol-1-Yl)Benzaldehyde 4-Bromo-1-Phenyl-1H-Imidazole 4-Methyl-1-Phenyl-1H-Imidazole 4-Methyl-1H-Imidazole 4-Phenyl-1H-Imidazole 5,6,7,8-Tetrahydroimidazo[1,2-A]Pyrazine 5,6,7,8-Tetrahydroimidazo[1,2-A]Pyridine 5,6,7,8-Tetrahydroimidazo[1,5-A]Pyrazine 5-Benzyl-1H-Imidazole 5-Bromoimidazo[1,2-A]Pyridine 5-Chloro-1H-Imidazole 5-Fluoro-1H-Benzo[D]Imidazole 5-Iodo-1H-Imidazole 5-Methylimidazo[1,2-A]Pyridine 5-Phenyl-1H-Imidazole 6,7-Dihydro-5H-Pyrrolo[1,2-A]Imidazole 6-Bromoimidazo[1,2-A]Pyrazine 6-Bromoimidazo[1,2-A]Pyridine 6-Bromoimidazo[1,2-A]Pyrimidine 6-Chloroimidazo[1,2-A]Pyridine 6-Chloroimidazo[1,2-B]Pyridazine 7-Methylimidazo[1,2-A]Pyridine 8-Bromoimidazo[1,2-A]Pyrazine 8-Bromoimidazo[1,2-A]Pyridine 8-Chloroimidazo[1,2-A]Pyrazine 8-Chloroimidazo[1,2-A]Pyridine 8-Fluoroimidazo[1,2-A]Pyridine 8-Methylimidazo[1,2-A]Pyridine Ethyl 1H-Imidazole-2-Carboxylate Ethyl 2-(Imidazo[1,2-A]Pyridin-3-Yl)Acetate Ethyl Imidazo[1,2-A]Pyridine-2-Carboxylate Ethyl Imidazo[1,2-A]Pyridine-3-Carboxylate Imidazo[1,2-A]Pyridin-3-Amine Imidazo[1,2-A]Pyridin-8-Amine Imidazo[1,2-A]Pyridin-8-Ol Imidazo[1,2-A]Pyridine-2-Carbaldehyde Imidazo[1,2-A]Pyridine-2-Carboxylic Acid Imidazo[1,2-A]Pyridine-3-Carbaldehyde Imidazo[1,2-A]Pyridine-3-Carboxylic Acid Imidazo[1,2-A]Pyridine-7-Carboxylic Acid Imidazo[1,2-A]Pyridine-8-Carboxylic Acid Imidazo[1,2-A]Pyrimidine-3-Carboxylic Acid Imidazo[1,2-C]Pyrimidine Imidazo[1,5-A]Pyrazine Imidazo[2,1-B]Thiazole Methyl 1H-Imidazole-2-Carboxylate Methyl 1H-Imidazole-5-Carboxylate Methyl Imidazo[1,2-A]Pyridine-8-Carboxylate Tert-Butyl 1H-Imidazole-1-Carboxylate

By Key Group+−

Amino-Imidazole Aminoimidazole-Carboxylate Benzyl-Imidazole Benzyl-Methyl-Imidazole Biimidazole Bromo-Imidazole Bromo-Imidazopyridine Bromo-Methyl-Imidazole Bromoimidazo Bromoimidazole Carboxylate Chloro-Imidazopyridine Chloroimidazo Dibromoimidazo Dichloroimidazo Dihydroimidazo Dimethyl-Imidazol Dimethylimidazo Dimethylimidazolium Dioxaborolane-Imidazole Ethyl-Imidazole Fluoroimidazo Hydroxy-Imidazopyridine Imidazol-Amine Imidazol-Ethanol Imidazol-Hydrochloride Imidazol-Ium Imidazol-Methanamine Imidazol-Methanol Imidazol-Pyridine Imidazole-Carboxylate Imidazole-Carboxylic Acid Imidazolyl-Ethanol Imidazolyl-Nitrile Imidazolyl-Pyrimidine Imidazopyrazine Imidazopyridazine Imidazopyridin-Amine Imidazopyridin-One Imidazopyridine Imidazopyridine-Carbonitrile Imidazopyridine-Carboxylate Imidazopyridine-Carboxylic Acid Imidazopyridine-Carboxylic-Acid Imidazopyrimidine Imidazoquinoline Imidazothiazole Iodoimidazo Iodomethyl-Imidazole Isopropyl-Imidazole Methoxyimidazo Methyl-Imidazopyridine Methyl-Nitro-Imidazole Methylimidazo Methylimidazole Methylimidazolium Nitro-Imidazole-Carboxylate Nitroimidazole Phenylimidazo Phenylimidazole Piperidin-Imidazolyl Pyrroloimidazole Tetrahydroimidazo Thienoimidazol Trifluoromethyl-Imidazo Trifluoromethyl-Imidazole Trifluoromethyl-Imidazopyridine

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Dioxolanes Indazoles Other Aliphatic Heterocycles Other Aromatic Heterocycles Piperazines Piperidines Pyrazines Pyrazoles Pyridines Pyrimidines Pyrrolidines Spiroes Tetrahydropyrans Thiophenes Thiophenols Triazines Triazoles

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Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkynyls Amides Amines Aryls Benzyl Bromides Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Hydrazines Iodides Ketones Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Sulfoxides Thioureas Trifluoromethyls Ureas

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Im

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